The mad scientist Dr. Tongue has created a wide variety of monsters within the bowels of his castle and has unleashed them on nearby suburban areas, terrorizing its inhabitants. Two teenage friends, Zeke and Julie, having witnessed the attack of said monsters, arm themselves with a great deal of unconventional weaponry and items to combat them and save their neighbors from certain death. Ultimately, they will come face to face with Dr. Tongue himself and defeat him to put an end to his plans.
The player can choose between Zeke and Julie, or play both in a two-player mode. They navigate suburban neighborhoods, shopping malls, pyramids, haunted castles, and other areas, destroying a variety of horror-movie monsters, including vampires, werewolves, huge demonic babies, spiders, squidmen, evil dolls, aliens, UFOs, giant ants, blobs, giant worms, mummies, chainsaw-wielding maniacs, "pod people" (aggressive alien clones of the players), and the game's namesake, zombies. In each of the 48 stages, which includes seven optional bonus levels, the players must rescue numerous types of neighbors, including barbecue chefs, teachers, babies, tourists, archeologists, soldiers, dogs, and cheerleaders. Once all neighbors on a level have been killed by zombies or saved by the players touching them, a door opens that will take the player to the next stage.[3]