WWE 2K20's 2K Showcase mode revolves around the Four Horsewomen of WWE (Bayley, "The Man" Becky Lynch, "The Queen" Charlotte Flair and "The Boss" Sasha Banks), from Charlotte VS. Natalya for the NXT Women's Championship at NXT to a triple threat winner takes all match between "The Man" Becky Lynch, "The Queen" Charlotte Flair and "The Baddest Woman on the Planet" "Rowdy" Ronda Rousey for the Raw and SmackDown Women's Championships at WrestleMania 35.[2] Players take control of different unique models of Bayley, Banks, Lynch, and Flair, in 15 matches. The 2K Towers mode, first introduced in WWE 2K19, made its return to the series.[3] WWE 2K20 features a female MyCareer story alongside its male story, the first for 2K. (Previous THQ games had female stories)[4] The story is set in April 2029, where Red and Tre were inducted to the WWE Hall of Fame as members of the Class of 2029, which happened before WrestleMania 45 in Las Vegas, Nevada (also known in-game as WrestleMania 2029, as a fictional version of that year's event), 11 years after the end of the WWE 2K19 MyCareer storyline, as in which, the matches follow the perspectives of their career before putting their spots on the line against Samoa Joe and Brooklyn Von Braun at WrestleMania 45 at the end of the story.
The WWE Towers Mode Returned, with one of the towers, known as a "Story Tower", centered around Roman Reigns, with matches with unique commentary from Extreme Rules in 2013, as a member of The Shield, with Seth Rollins, with Dean Ambrose by their side, against Team Hell No (Daniel Bryan and Kane), to Stomping Grounds in 2019, against Drew McIntyre. All matches use the superstars' modern day counterparts and took place at WrestleMania 35.