One major difference between the game and its predecessor is the ability to play on ground levels. In the first game's outdoor levels, if Spider-Man swung too low below designated rooftops, he would fall into yellow mist that dominated most of the game's levels and die. This game, however, presented levels based in limited city streets. They were confined grids rather than a free-roam environment.
The enemies in Enter Electro are more realistic than the ones in the previous game, with the lizardmen and alien symbiotes being replaced by criminals, drones and robots. In this game, Spider-Man has the ability to shoot a Web Ball while in mid-air. Spider-Man can also attach electricity and ice to his webbing. This time, the training mode takes the player to the X-Men's Danger Room Simulator wherein Rogue and Professor X assist Spider-Man with everything that may be useful during the course of gameplay. The hand animation is also changed. Now, every character's hands can react instead of waving fists. The basic punch and kick combo moves are also changed, doing away with the two-handed uppercut/mule kick for the third strike. Spider-Man only has one jump animation in this game, with him having two in the predecessor. The game primarily features only four credited voice actors: Rino Romano as Spider-Man and Jennifer Hale as Dr. Watts and Rogue, meanwhile Daran Norris and Dee Bradley Baker provided the rest of the voices.
By completing certain in-game goals, new costumes can be unlocked for Spider-Man. Many of them have special powers to alter the game experience. Included are all the costumes from the first game, with the same abilities, as well as several new outfits. A new option called "Create-A-Spider" mode allows the player to apply up to three in-game powers to any unlocked costume. The game powers include enhanced strength, unlimited webbing and invincibility.
Two additional costumes designed by comic-book artist Alex Ross were also featured in the game, one of which was a prototype costume design for the then-upcoming 2002 Spider-Man movie.
