In Warhammer 40,000: Space Marine II, the player engages enemies using a mix of both melee and ranged combat from a third-person point of view.[2] The player controls Titus, a lieutenant of the Ultramarines chapter and returning protagonist from the first game. Titus is accompanied by fellow Space Marines Chairon and Gadriel throughout the campaign who can be controlled by other players in the game's cooperative multiplayer mode or by artificial intelligence (AI) in single player.[3][4]