Punch-Out!! features a boxer named Little Mac working his way up the professional boxing circuits, facing a series of colorful, fictional boxers. The game requires reflexes to react to the computer-controlled boxers' moves. All of the boxers from the NES gameexcept for Mike Tyson return, along with Bear Hugger and Aran Ryan from Super Punch-Out!! and new opponents Disco Kid, Giga Mac, and Donkey Kong. The game allows three different control schemes. The Wii Remote and Nunchuk can be used together, a Wii Balance Board can be used along with the Wii Remote and Nunchuk to duck or dodge, or the Wii Remote can be used by itself and held sideways in a traditional two-button control scheme.
In each stage, players must rely on quick reactions and identify various tells from their opponent to dodge or block their attacks, before returning with attacks to either the torso or the head with the left and right fists. Stars are awarded for landing a punch at particular moments, such as when an opponent grins or taunts Little Mac. The player can store up to three stars, but will lose them if hit by the opponent. When the player has one or more stars, they can perform a Star Punch, which deals extra damage. Each fighter has a stamina gauge which results in a knockdown when fully depleted, with the player able to recover stamina while the opponent is down. Additionally, the player has a heart counter that decreases upon being hit or throwing a punch that is dodged or blocked. If the counter reaches zero, the player will be unable to attack and be vulnerable until they can successfully dodge an attack. A fight can end by knockout (KO) if a fighter is unable to rise within 10 seconds after being knocked down; by technical knockout (TKO), if a fighter is knocked down three times in one round; or by decision, if neither fighter achieves a KO or TKO after three rounds. Against certain opponents, the player can score an automatic KO by landing a Star Punch at the right moment, regardless of the opponent's stamina. The player can recover from being knocked down a maximum of three times per fight, but will lose on a fourth knockdown.
Two single-player campaign options are available. The Career option begins in Contender mode, in which Little Mac must climb the ranks of the World Video Boxing Association by rising through the Minor, Major, and World Circuits. Once Mac wins the world championship title, the game enters the more challenging Title Defense mode; he must now defend his belt against the other fighters, who use new techniques and defenses (such as King Hippoprotecting his stomach with a manhole cover).[13] Completing Title Defense unlocks Mac's Last Stand, an endurance mode in which Mac faces off against an endless series of randomly chosen opponents, one of whom is Donkey Kong. Once Mac loses three times, he retires from boxing and the Career option for the player's save file will become disabled, requiring the player to create a new file to play this option again. The Exhibition option allows players to fight against any opponents they have already defeated in either Contender or Title Defense, attempting to complete unique achievements, or practice against a holographic image of their current opponent. If the player wins 10 fights in Mac's Last Stand, an additional Champions Mode option is unlocked for Exhibition, in which a single hit will knock Mac down.
New to the series is a split-screen multiplayer mode between Little Mac and a recolored clone. When one of the players has gathered enough power by repeatedly dodging all moves unscathed, that player's character transforms into a giant known as "Giga Mac" for a limited time and the game shifts to the opponent's single-player view until he returns to normal.[14]
