Prototype is an action-adventure game played from a third-person perspective and set in an open world based on modern-day Manhattan. The game's setting remains mostly faithful to the real city and includes all of its famous landmarks, including the Empire State Building, the Chrysler Building, 40 Wall Street, 28 Liberty Street, the Conde Nast Building, the Metlife Building, One New York Plaza, and the New York Life Building, among others.