In 1934, exactly one century after the previous game, Adam Crowley, an occultist and antagonist from the previous game, has created a vast race of mutant creatures, which he is using to wipe out a group of monster hunters called the Circle. Meanwhile, Herbert Wallace, a patient at Crowley's genetics hospital, escapes from captivity, armed with an axe. He arrives in London, where he discovers evidence of a picture of Ignatius Blackward who, with Nadia Franciscus, had defeated Crowley in the previous game. Thanks to Rachel, the only surviving member of the Circle, Wallace is rescued from fire. They head their separate ways, with Wallace venturing to Crowley's castle, only to discover that Crowley himself is not there, but in Paris.
He then falls down a chute, which leads to a biplane that he flies to France. Wallace enters a cinema, where he finds a note from Rachel informing him that she knows of Crowley's plans. He then proceeds onwards to a museum to meet up with Rachel, but unknown to Wallace, she has been captured by zombies. Wallace then enters the museum, where he finds a detailed blueprint of the Eiffel Tower, along with some of Crowley's plans. Wallace enters a crypt, but zombies surround him and he plants one head first into a wall, escapes in a car while another zombie attacks him from behind and crashes in an elaborate graveyard, where he finds a part of Rachel's shirt snagged on a tree.