In this single-player side-scrolling beat 'em up (with a format similar to Double Dragon and Final Fight), the player controls Spider-Man and Venom through various levels to stop the supervillain Carnage and his team, as well as hundreds of criminals they inspire in their wake, from taking over the city. The two 16-bit versions are virtually identical.
One of the game's comic-styled cutscenes. This one is based on the final panel of Spider-Man Unlimited #1.
Other Marvel heroes can be summoned by collecting appropriate items hidden within certain levels. The locations of the power-ups necessary to summon aid are set. Depending on which character summoned them, the summoned heroes may help out in different ways, usually being more effective for whichever character (Spider-Man or Venom) they favor.