Like the previous two entries, gameplay is reminiscent of a top-down dungeon crawler with an emphasis on cooperative play. Up to four players can play the game cooperatively locally either on the same screen with a single docked Nintendo Switch system or undocked with up to four systems, or online with friends or random player lobbies. Players choose four characters from various Marvel teams to traverse linear stages, fight enemies, and defeat bosses. Certain passive buffs are acquired with particular character combinations. Each character's controls are fundamentally identical; each has a jump, light attack, heavy attack, dodge, block, and four special abilities. Special abilities can be synced with the other three members for a synergy boost, with an especially powerful attack unleashed if all four party members sync up simultaneously. The combat system itself, as evident by the characters' normal attacks and their damage properties, as well as lack of universal normal grab is similar to Koei Tecmo's Warriors series. Additional characters are unlocked by story progression or optional Infinity Rift challenges.
Character progression is handled in a similar manner to traditional role-playing games, with party members leveling up by defeating enemies and bosses. In addition to stat increases, passive buffs can be attached to characters (excluding an alternate playable version of Thanos) by equipping ISO-8 crystals. A sprawling skill tree is also present, which allows characters to gain permanent stat increases by acquiring and spending in-game currency.