imilar to the PC version of the previous game, Jimmy Neutron vs. Jimmy Negatron is a third-person 3D video game which has gameplay largely consisting of puzzles and problem-solving, with Jimmy having to solve various puzzles to progress, such as gathering required items or passing obstacles. Besides puzzle solving, there are enemies that the player must avoid or battle with in boss fights to progress through certain locations. Throughout the game, the player primarily plays Jimmy Neutron, the protagonist.