The plot centers around Indy's search for the Staff of Moses, a journey which takes him to several locations including the Sudan, Panama, San Francisco, and Nepal. The game incorporates a linear structure which includes puzzles to solve, obstacles to clear, and enemies that must either be defeated through hand-to-hand combat, shot down with Indy's sidearm, or defeated using the environment around them. Motion controls in the Nintendo versions (via the Wii Remote and Nunchuk, or the DS stylus, depending on the platform) allow the player to throw punches, use the bullwhip, and perform a wide variety of actions.[3]
The Wii version of the game includes an exclusive co-op story mode (with Indy and Henry Jones Sr.) and unlockable version of the classic point and click adventure Indiana Jones and the Fate of Atlantis (also set in 1939). On the console versions, Big Head mode, Henry Jones Sr., Tuxedo Indy, and Han Solo from Star Wars are unlockable.