The game takes full advantage of the Wii Remote and its Nunchuk attachment. For example, the player can make the character jump by lifting the Nunchuk. Weapons are aimed by pointing the Wii Remote at the screen, and melee attacks are carried out by making a slashing motion with it. The zoom on sniper rifles is controlled by moving the Wii Remote towards the television. Split screen Chaos mode (standard deathmatch) is included. The popular map maker mode, as well as online play, are absent from the Wii version of the game, and no WiiConnect24 features are utilized.
Vengeance features some exclusive content not present in the original version of Far Cry Instincts: Evolution, including three new levels, three multiplayer maps, and new weapons, such as the Bull .44 large-caliber revolver, the AK-47, and a shotgun.