During the year 1959, Cryptosporidium 137 first arrived on the Earth to investigate the planet and search for his predecessor clone, Cryptosporidium 136, who disappeared in 1947 after Orthopox 13 sent him to Earth on a similar mission. Pox sends Crypto on a mission to harvest human brain stems (which contain a small amount of pure Furon DNA due to an encounter between Furon warriors and humans in ancient times) to prevent his species from going extinct. To accomplish his mission, he must defeat Majestic, a shadowy government organization led by a black-clad figure named Silhouette. After accomplishing this, Crypto takes over the United States by posing as the President.