In Cybernoid, pirates have raided the storage depots of the Federation and stolen minerals, jewels, ammunition and the latest battle weaponry. The Cybernoid ship has been dispatched with instructions to retrieve the stolen booty and to return it to storage within a specified time limit. The Cybernoid needs to battle the pirates and their planetary defense systems in order to retrieve the stolen booty.
Cybernoid is split into three levels, with each level consisting of several screens that are traversed via a flip-screen system of play rather than scrolling. The hazards in each screen can be different - some will have just enemy pirate ships, some homing missiles, some gun turrets, some indestructible enemies on fixed-paths that have to be traversed and some a mixture of these. The Cybernoid ship can collect power-ups for assistance (including a rear-gun and a giant spiked ball that flies around the ship) and also use a variety of built-in special weapons such as shields and homing missiles.
Shooting pirate ships often leaves power-ups or jewels that Cybernoid can then collect.
The NES version was made by Studio 12 productions, consisting of Chris Harvey as the programmer and Adrian Carless for the graphics. They put a few in-jokes into the title page, the main one being that the Cybernoid ship was designed by "M.Sugden", referencing the British Actress Mollie Sugden, who played Mrs Slocombe on the TV series Are You Being Served?.