The game opens with young brothers Jacob and Luke Marshall on a hunting trip in Alaska with their father, a park ranger. The three of them are attacked by an unusually aggressive scar-faced grizzly bear. Luke saves Jacob by pulling him up a cliff instead of taking a shot at the bear. Instead, the bear kills their father, who jumps in its path to protect them and manages to kill it with his final shot.
Ten years later, Jacob and Luke have become estranged from each other, but have agreed to reunite for a hunting safari in Uganda on their father's birthday. Jacob has become a conservationist while Luke has gained a reputation as a hunter of man-eaters. Before they can begin their safari, Luke receives word that a local man was dragged away from his children by a black lion, a creature previously thought to be mythical. Being reminded of the death of his own father, Luke is enraged and takes off alone in pursuit of the man-eater; Jacob follows to assist him, against Luke's wishes.
The game periodically cuts between Jacob's pursuit of Luke through the African jungle and flashbacks to the earlier hunting trip in Alaska with Jacob, Luke, and their father, where Jacob saved Luke's life from a pack of wolves and the three of them first encountered the scar-faced grizzly bear that would later kill their father.
Jacob ultimately enters an ancient ruined city, where he encounters the black lion and its pride. Luke is dragged off by the black lion, but Jacob succeeds in defeating the beast and saving his brother. Mirroring their encounter with the grizzly ten years earlier, Jacob chooses to pull his brother up a cliff instead of taking the final shot on the black lion; however, he still manages to kill the lion after saving his brother.